METABOLISM OF CYTOSINE, THYMINE, URACIL, AND BARBITURIC ACID BY BACTERIAL ENZYMES
نویسندگان
چکیده
منابع مشابه
Metabolism of cytosine, thymine, uracil, and barbituric acid by bacterial enzymes.
Early stud& with pyrimidines administered t.o animals established the fact that, these compounds arc metabolized (3, 4). Present concepts of the pathways of pyrimidine metabolism stem largely from the work of Cerecedo (4), in which he measured the changes in the urinary excretion of urea after feeding pyrimidines and related subst.ances. On the basis of these studies, he proposed an init.ial ox...
متن کاملStudies on a relationship of uracil and cytosine nucleosides to biosynthesis of deoxyribonucleic acid thymine.
Formate (l), serine (2)) formaldehyde (3), and methionine (4) each can serve as the donor of the carbon atom for the biosynthesis of the methyl group of DNA’-thymine. The utilization of formate for the biosynthesis of DNA in vitro has been reported previously (5-g), and in most instances the uptake of formate carbon under these conditions has been primarily into the methyl group of thymine (5)....
متن کاملAn ab initio quantum chemical investigation of TOMS nmr SHIELDING TENSORS IN Adenine-thymine, Adenine-uracil, Guanine-Cytosine & uracil-quartet: comparison between theoretical and experimental results
We have evaluated the NMR shielding tensors for A:T,G:C,A:U in Watson-crick, and U-quartet. We have computed NMR shielding tensors at B31YP level by using 6-31G(d) basis set. We have compute anisotropy and asymmetry in A:T,G:C,A:U and U-quartet. The NMR shielding tensors were calculated using the GIAO method. The natural bonding orbital analysis (NBO) were performed. NBO calculation have been ...
متن کاملSurface-Enhanced Hyper-Raman Spectra of Adenine, Guanine, Cytosine, Thymine, and Uracil
Using picosecond excitation at 1064 nm, surface-enhanced hyper-Raman scattering (SEHRS) spectra of the nucleobases adenine, guanine, cytosine, thymine, and uracil with two different types of silver nanoparticles were obtained. Comparing the SEHRS spectra with SERS data from the identical samples excited at 532 nm and with known infrared spectra, the major bands in the spectra are assigned. Due ...
متن کاملMismatch dependent uracil/thymine-DNA glycosylases excise exocyclic hydroxyethano and hydroxypropano cytosine adducts.
Exocyclic adducts of DNA bases, such as etheno- and hydroxyalkano- ones, are generated by a variety of bifunctional agents, including endogenously formed products of lipid peroxidation. In this work we selectively modified cytosines in the 5'-d(TTT TTT CTT TTT CTT TTT CTT TTT T)-3' oligonucleotide using: chloroacetaldehyde to obtain 3,N(4)-alpha-hydroxyethano- (HEC) and 3,N(4)-etheno- (epsilonC...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1952
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)55628-3